{"id":17138,"date":"2025-09-24T09:00:11","date_gmt":"2025-09-24T00:00:11","guid":{"rendered":"https:\/\/blog.agentsoft.co.kr\/index.php\/2025\/09\/24\/17138\/"},"modified":"2025-09-24T09:00:11","modified_gmt":"2025-09-24T00:00:11","slug":"pka%eb%a5%bc-%ec%9d%b4%ec%9a%a9%ed%95%9c-%ec%82%b0%ec%9d%98-%eb%b6%84%eb%a6%ac-%ec%8b%a4%ed%97%98%eb%a0%88%ed%8f%ac%ed%8a%b8","status":"publish","type":"post","link":"https:\/\/blog.agentsoft.co.kr\/index.php\/2025\/09\/24\/17138\/","title":{"rendered":"pKa\ub97c \uc774\uc6a9\ud55c \uc0b0\uc758 \ubd84\ub9ac \uc2e4\ud5d8\ub808\ud3ec\ud2b8"},"content":{"rendered":"

<\/p>\n

\ubaa9\ucc28<\/strong><\/p>\n

1. \uc81c\ubaa9 <\/p>\n

2. \uc2dc\uc57d <\/p>\n

3. \uc774\ub860
\n1> pKa
\n2> \uc0b0-\uc5fc\uae30 \ubc18\uc751
\n3> TLC
\n4> \ubd84\ud3ec\uacc4\uc218(distribution coefficient : K = C2\/C1)<\/p>\n

4. \uc2e4\ud5d8\uacfc\uc815<\/p>\n

5. \uacb0\uacfc
\n1> \uc2e4\ud5d8\uacfc\uc815 \ubd84\uc11d
\n2> \uace0\ucc30<\/p>\n

\ubcf8\ubb38\ub0b4\uc6a9<\/strong><\/p>\n

3> TLC
\n TLC\ub294 \ud63c\ud569\ubb3c\uc744 \ubd84\ub9ac\ud558\uae30 \uc704\ud574 \uc0ac\uc6a9\ub41c\ub2e4. \uace0\uc815\uc0c1\uacfc \uc774\ub3d9\uc0c1\uc744 \uc774\uc6a9\ud558\uc5ec \uc774\ub3d9\uc18d\ub3c4 \ucc28\uc774\ub97c \uae30\uc900\uc73c\ub85c \ud63c\ud569\ubb3c\uc744 \ubd84\ub9ac\ud55c\ub2e4. \ud63c\ud569\ubb3c\uc774 \uc774\ub3d9\uc0c1\uc5d0 \ub179\uc544\uc788\uc73c\uba70 \uac01 \ud63c\ud569\ubb3c\uc758 \uc131\ubd84\ub4e4\uc740 \uc774\ub3d9\uc18d\ub3c4\uac00 \ubaa8\ub450 \ub2e4\ub974\uae30 \ub54c\ubb38\uc5d0 \ubd84\ub9ac\ud560 \uc218 \uc788\ub2e4. \uace0\uc815\uc0c1(\uc815\uc9c0\uc0c1)\uc740 \uc131\ubd84\uc744 \ubd84\ub9ac\ud560 \ub54c \uace0\uc815\ub41c \uc704\uce58\uc5d0 \uc720\uc9c0\ud558\ub294 \uc0c1\uc73c\ub85c \ubaa8\uc138\uad00\uc774\ub098 \uceec\ub7fc \ub4f1\uc5d0 \ucc44\uc6cc\uc838 \uace0\uc815\ub418\uc5b4 \uc788\uae30 \ub54c\ubb38\uc5d0 \uc774\ub3d9\ud558\uc9c0 \uc54a\uace0, \uc2dc\ub8cc \ubc0f \uc774\ub3d9\uc0c1\uacfc \uc0c1\ud638\uc791\uc6a9\ud55c\ub2e4. \uace0\uc815\uc0c1\uc73c\ub85c\ub294 \uc2e4\ub9ac\uce74\uc824(SiO2), \uc54c\ub8e8\ubbf8\ub098(Al2O3), Charcoal, \ud569\uc131 \uaddc\uc0b0 \ub9c8\uadf8\ub124\uc298(MgO\/SiO2(anhydrous)) \ub4f1\uc774 \uc788\ub2e4. \uc774\ub3d9\uc0c1\uc740 \uc131\ubd84\uc744 \ubd84\ub9ac\ud560 \ub54c \uc2dc\ub8cc\ub97c \uc774\ub3d9\uc2dc\ud0a4\ub294 \uc0c1\uc73c\ub85c \uc561\uccb4 \ub610\ub294 \uae30\uccb4\ub97c \uc0ac\uc6a9\ud55c\ub2e4. \uc561\uccb4 \uc774\ub3d9\uc0c1\uc740 Hexane, Toluene, Methylene chloride, Dietyl ehter, Ethyl acetate, Acetone, Methanol, Water\uac00 \uc788\uc73c\uba70 \uc624\ub978\ucabd\uc5d0 \uc704\uce58\ud55c \ubb3c\uc9c8\uc77c\uc218\ub85d \uadf9\uc131\uc774 \ud06c\ub2e4. \uc774\ub3d9\uc0c1\uc740 \uc8fc\ub85c Hexane\uacfc Ethyl acetate\ub97c \uc11e\uc740 \ud63c\ud569\ubb3c\uc744 \uc0ac\uc6a9\ud55c\ub2e4. \uc2dc\ub8cc\ub294 \uc774\ub3d9\uc0c1\uc5d0 \uc758\ud574, \uc774\ub3d9\uc0c1\uc744 \ub530\ub77c \uc804\uac1c\uac00 \ub41c\ub2e4. \uc774 \uacfc\uc815\uc5d0\uc11c \uc911\uc694\ud55c \uac83\uc740 TLC chamber \uc548\uc5d0\ub294 \uc774\ub3d9\uc0c1\uc758 \ub18d\ub3c4\uac00 \ud56d\uc0c1 \uc77c\uc815\ud574\uc57c \ud55c\ub2e4. \uc774\ub3d9\uc0c1\uc758 \ub18d\ub3c4\ub97c \uc77c\uc815\ud558\uac8c \ud558\uae30 \uc704\ud574 filter paper\ub97c \uae54\uc544\uc8fc\uac70\ub098 jar cover\ub97c \ub36e\uc5b4\uc90c\uc73c\ub85c\uc368 \uc6a9\ub9e4\uac00 \ud718\ubc1c\ub418\ub294 \uac83\uc744 \ub9c9\uc744 \uc218 \uc788\ub2e4. \ube44\ucee4 \uc548\uc5d0 \uc774\ub3d9\uc0c1\uc73c\ub85c \uc801\uc154\uc9c4 filiter paper\ub97c \ub123\uc5b4 \ub450\uba74 \uc774\ub3d9\uc0c1\uc758 \uadf9\uc131 \ubcc0\ud654\ub85c \uc778\ud55c Rf \uac12\uc758 \ubcc0\ud654\ub97c \ub9c9\uc744 \uc218 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4. \uc5ec\uae30\uc11c Rf\ub780 Retention facotr\ub85c \uba38\ubb34\ub984 \uacc4\uc218\uc774\ub2e4. \uba38\ubb34\ub984 \uacc4\uc218\ub294 \uc6a9\uc9c8\uc774 \uc774\ub3d9\ud55c \uac70\ub9ac\uc640 \uc6a9\ub9e4\uac00 \uc774\ub3d9\ud55c \uac70\ub9ac\uc758 \ube44\uc728\uc774\ub2e4. \uc774\ub97c \ud1b5\ud574 Rf\uac12\uc774 \uadfc\uc811\ud558\uac70\ub098 \uac19\uc740 \ubb3c\uc9c8\uc740 \ub3d9\uc77c\ud55c \ubb3c\uc9c8\uc784\uc744 \ud655\uc778\ud558\ub294 \ub370\uc5d0 \ub3c4\uc6c0\uc774 \ub41c\ub2e4.<\/p>\n

3> \ubd84\ud3ec\uacc4\uc218(distribution coefficient : K = C2\/C1)
\n \uc6a9\ud574\ub3c4\uc758 \ube44\ub97c \ubd84\ud3ec\uacc4\uc218\ub77c \ud558\uba70 K = C2\/C1\uc73c\ub85c \ud45c\ud604\ud560 \uc218 \uc788\ub2e4.<\/p>\n

\ucd9c\ucc98 : \ud574\ud53c\ucea0\ud37c\uc2a4<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\ubaa9\ucc28 1. \uc81c\ubaa9 2. \uc2dc\uc57d 3. \uc774\ub860 1> pKa 2> \uc0b0-\uc5fc\uae30 \ubc18\uc751 3> TLC 4> \ubd84\ud3ec\uacc4\uc218(distribution coefficient : K = C2\/C1) 4. \uc2e4\ud5d8\uacfc\uc815 5. \uacb0\uacfc 1> \uc2e4\ud5d8\uacfc\uc815 \ubd84\uc11d 2> \uace0\ucc30 \ubcf8\ubb38\ub0b4\uc6a9 3> TLC TLC\ub294 \ud63c\ud569\ubb3c\uc744 \ubd84\ub9ac\ud558\uae30 \uc704\ud574 \uc0ac\uc6a9\ub41c\ub2e4. \uace0\uc815\uc0c1\uacfc \uc774\ub3d9\uc0c1\uc744 \uc774\uc6a9\ud558\uc5ec \uc774\ub3d9\uc18d\ub3c4 \ucc28\uc774\ub97c \uae30\uc900\uc73c\ub85c \ud63c\ud569\ubb3c\uc744 \ubd84\ub9ac\ud55c\ub2e4. \ud63c\ud569\ubb3c\uc774 \uc774\ub3d9\uc0c1\uc5d0 \ub179\uc544\uc788\uc73c\uba70 \uac01 \ud63c\ud569\ubb3c\uc758 \uc131\ubd84\ub4e4\uc740 \uc774\ub3d9\uc18d\ub3c4\uac00 \ubaa8\ub450 \ub2e4\ub974\uae30 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[22094,15066,21494],"class_list":["post-17138","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-pka----","tag-15066","tag-21494"],"_links":{"self":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/posts\/17138","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/comments?post=17138"}],"version-history":[{"count":0,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/posts\/17138\/revisions"}],"wp:attachment":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=17138"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/categories?post=17138"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/tags?post=17138"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}