{"id":18353,"date":"2025-10-06T09:00:29","date_gmt":"2025-10-06T00:00:29","guid":{"rendered":"https:\/\/blog.agentsoft.co.kr\/index.php\/2025\/10\/06\/18353\/"},"modified":"2025-10-06T09:00:29","modified_gmt":"2025-10-06T00:00:29","slug":"%ec%9d%b8%ec%b2%9c%eb%8c%80%ed%95%99%ea%b5%90-%eb%82%98%eb%85%b8%eb%b0%94%ec%9d%b4%ec%98%a4%ec%8b%a4%ed%97%982-a-%ec%9e%90%eb%a3%8c-7-plga-doxorubicin-%eb%82%98%eb%85%b8-%ec%9e%85%ec%9e%90","status":"publish","type":"post","link":"https:\/\/blog.agentsoft.co.kr\/index.php\/2025\/10\/06\/18353\/","title":{"rendered":"\uc778\ucc9c\ub300\ud559\uad50 \ub098\ub178\ubc14\uc774\uc624\uc2e4\ud5d8(2) A+ \uc790\ub8cc) 7. PLGA-doxorubicin \ub098\ub178 \uc785\uc790\ub97c \uc774\uc6a9\ud55c \uc138\ud3ec \ub3c5\uc131 \ud3c9\uac00"},"content":{"rendered":"

<\/p>\n

\ubaa9\ucc28<\/strong><\/p>\n

1. Abstract<\/p>\n

2. Introduction<\/p>\n

3. Materials & Methods<\/p>\n

4. Results<\/p>\n

5. Discussions
\n 1) \uac19\uc740 \ub18d\ub3c4\uc758 \ud56d\uc554\uc81c\uac00 \ud3ec\ud568\ub41c \ub098\ub178 \uc785\uc790\uc640 free doxorubicin\uc758 \ub3c5\uc131\uc744 \ube44\uad50\ud588\uc744 \ub54c, \uc65c free doxorubicin\uc5d0\uc11c \uc138\ud3ec \ub3c5\uc131\uc774 \ub354 \ub192\uac8c \ub098\ud0c0\ub098\ub294\uc9c0 \uadf8 \uc774\uc720\ub97c \uc608\uce21\ud574\ubcf4\uc544\ub77c.
\n 2) \uc77c\ubc18\uc801\uc73c\ub85c Doxorubicin\uacfc \uac19\uc740 \ud56d\uc554\uc81c\ub294 \uc7a5\uae30\uac04 \uc0ac\uc6a9 \uc2dc \ud6c4\ucc9c\uc131 \ub0b4\uc131\uc774 \ubc1c\ud604\ub418\uc5b4 \uc57d\ubb3c\uc758 \uc554\uc138\ud3ec \ub0b4 \uc720\uc785\uc744 \uac10\uc18c\uc2dc\ud0a4\uace0 \uc57d\ubb3c\uc758 \ud544\uc694\ub97c \uc99d\uac00\uc2dc\ud0a8\ub2e4. \uc554\uc138\ud3ec\uc758 \ub2e4\uc218 \uc57d\ubb3c\uc5d0 \uc800\ud56d\uc131 (Multi-drug resistance, MDR)\uc5d0 \ub300\ud574 \uc870\uc0ac\ud558\ub77c.<\/p>\n

6. References<\/p>\n

\ubcf8\ubb38\ub0b4\uc6a9<\/strong><\/p>\n

\uc774\ubc88 \uc2e4\ud5d8\uc5d0\uc11c\ub294 PLGA-doxorubicin \ub098\ub178 \uc785\uc790\ub97c \uc774\uc6a9\ud558\uc5ec \uc554\uc138\ud3ec \uce58\ub8cc \ud6a8\uacfc\ub97c \ub2e4\uc591\ud55c(0.04 ug, 0.16 ug, 0.3 ug) DOX \ub18d\ub3c4\ubcc4\ub85c \ud3c9\uac00\ud558\uc600\ub2e4. \uadf8\ub9ac\uace0 \ub098\ub178 \uc785\uc790\ub97c \ud1b5\ud55c \uc57d\ubb3c \uc804\ub2ec\uacfc free DOX\ub97c \ud1b5\ud55c \uc138\ud3ec \uce58\ub8cc \ud6a8\uacfc\ub97c \uac01\uac01 \ube44\uad50\ud574 \ubcf4\uc558\ub2e4. MTT assay\ub294 \uc0b4\uc544\uc788\ub294 \uc138\ud3ec\uc5d0\uc11c\ub9cc \ud658\uc6d0 \ubc18\uc751\uc774 \uc77c\uc5b4\ub098\ub294 MTT\uc5d0 \uc758\ud55c \uc138\ud3ec \ub300\uc0ac \ud65c\uc131\uc744 \ud3c9\uac00\ud558\ub294 \ubc29\ubc95\uc73c\ub85c, \ud56d\uc554\uc81c\ub97c \ud22c\uc5ec\ud558\uc9c0 \uc54a\uc740 \ubc30\uc9c0\uc640 \ub18d\ub3c4\ubcc4\ub85c \ud56d\uc554\uc81c\ub97c \ucc98\ub9ac\ud55c \ubc30\uc9c0\uc758 UV \ud761\uad11\ub3c4 \uac12\uc744 \ube44\uad50\ud558\uc5ec \uc138\ud3ec\uc758 \uc0dd\uc874 \ube44\uc728(cell viability)\uc744 \uacc4\uc0b0\ud560 \uc218 \uc788\ub2e4.
\n\uc2e4\ud5d8 \uacb0\uacfc\ub294 \ud06c\uac8c \ub450 \ud56d\ubaa9\uc73c\ub85c \ub098\ub20c \uc218 \uc788\ub2e4. \uba3c\uc800, \uac01 DOX \ucc98\ub9ac\ud558\ub294 \ubc29\ubc95 \ubcc4\ub85c DOX\uc758 \ub18d\ub3c4\uc758 \ubcc0\ud654\uc5d0 \ub530\ub77c cell viability\ub97c \ube44\uad50\ud560 \uc218 \uc788\ub2e4. DOX-PLGA NPs\uc640 Empty PLGA NPs\ub97c \ucc98\ub9ac\ud558\uc600\uc744 \ub54c\ub294, DOX\uc758 \ub18d\ub3c4\uac00 \uc99d\uac00\ud560\uc218\ub85d cell viability\uac00 \uac10\uc18c\ud558\uc600\ub2e4. \ubc18\uba74 Free DOX\ub97c \ucc98\ub9ac\ud558\uc600\uc744 \ub54c\ub294, DOX\uc758 \ub18d\ub3c4\uac00 \ubcc0\ud654\ud574\ub3c4 \uc77c\uc815\ud55c cell viability\ub97c \ubcf4\uc600\ub2e4. \ub450 \ubc88\uc9f8\ub85c, \uac01 \ub18d\ub3c4 \ubcc4\ub85c DOX\uc758 \ucc98\ub9ac \ubc29\ubc95\uc5d0 \ub530\ub978 cell viability\ub97c \ube44\uad50\ud574\ubcf4\uc558\ub2e4. 0.04 ug\uc758 DOX\ub97c \ucc98\ub9ac\ud558\uc600\uc744 \ub54c\ub294, Empty PLGA NPs, DOX-PLGA NPs, Free DOX \uc21c\uc73c\ub85c cell viability\uac00 \uac10\uc18c\ud558\uc600\ub2e4. 0.16 ug\uc758 DOX\ub97c \ucc98\ub9ac\ud558\uc600\uc744 \ub54c\ub294, Empty PLGA NPs, Free DOX, DOX-PLGA NPs \uc21c\uc73c\ub85c cell viability\uac00 \uac10\uc18c\ud558\uc600\ub2e4. 0.3 ug\uc758 DOX\ub97c \ucc98\ub9ac\ud558\uc600\uc744 \ub54c\ub294, Free DOX, Empty PLGA NPs, DOX-PLGA NPs \uc21c\uc73c\ub85c cell viability\uac00 \uac10\uc18c\ud558\uc600\ub2e4.<\/p>\n

\ucd9c\ucc98 : \ud574\ud53c\ucea0\ud37c\uc2a4<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\ubaa9\ucc28 1. Abstract 2. Introduction 3. Materials & Methods 4. Results 5. Discussions 1) \uac19\uc740 \ub18d\ub3c4\uc758 \ud56d\uc554\uc81c\uac00 \ud3ec\ud568\ub41c \ub098\ub178 \uc785\uc790\uc640 free doxorubicin\uc758 \ub3c5\uc131\uc744 \ube44\uad50\ud588\uc744 \ub54c, \uc65c free doxorubicin\uc5d0\uc11c \uc138\ud3ec \ub3c5\uc131\uc774 \ub354 \ub192\uac8c \ub098\ud0c0\ub098\ub294\uc9c0 \uadf8 \uc774\uc720\ub97c \uc608\uce21\ud574\ubcf4\uc544\ub77c. 2) \uc77c\ubc18\uc801\uc73c\ub85c Doxorubicin\uacfc \uac19\uc740 \ud56d\uc554\uc81c\ub294 \uc7a5\uae30\uac04 \uc0ac\uc6a9 \uc2dc \ud6c4\ucc9c\uc131 \ub0b4\uc131\uc774 \ubc1c\ud604\ub418\uc5b4 \uc57d\ubb3c\uc758 \uc554\uc138\ud3ec \ub0b4 \uc720\uc785\uc744 \uac10\uc18c\uc2dc\ud0a4\uace0 \uc57d\ubb3c\uc758 \ud544\uc694\ub97c \uc99d\uac00\uc2dc\ud0a8\ub2e4. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[22611,8739,23372,22599,13052,20020,20021,23371,8319],"class_list":["post-18353","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-doxorubicin","tag-erp","tag-mdr","tag-plga","tag-13052","tag-20020","tag-20021","tag-23371","tag-8319"],"_links":{"self":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/posts\/18353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/comments?post=18353"}],"version-history":[{"count":0,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/posts\/18353\/revisions"}],"wp:attachment":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=18353"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/categories?post=18353"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/tags?post=18353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}