{"id":18357,"date":"2025-10-06T09:00:36","date_gmt":"2025-10-06T00:00:36","guid":{"rendered":"https:\/\/blog.agentsoft.co.kr\/index.php\/2025\/10\/06\/18357\/"},"modified":"2025-10-06T09:00:36","modified_gmt":"2025-10-06T00:00:36","slug":"%ec%9d%b8%ec%b2%9c%eb%8c%80%ed%95%99%ea%b5%90-%eb%82%98%eb%85%b8%eb%b0%94%ec%9d%b4%ec%98%a4%ec%8b%a4%ed%97%982-a-%ec%9e%90%eb%a3%8c-10-liquid-chromatography-mass-spectrometry-lc-ms%ec%9d%84","status":"publish","type":"post","link":"https:\/\/blog.agentsoft.co.kr\/index.php\/2025\/10\/06\/18357\/","title":{"rendered":"\uc778\ucc9c\ub300\ud559\uad50 \ub098\ub178\ubc14\uc774\uc624\uc2e4\ud5d8(2) A+ \uc790\ub8cc) 10. Liquid chromatography-mass spectrometry (LC\/MS)\uc744 \uc774\uc6a9\ud55c \uce74\ud398\uc778 \uac80\ucd9c"},"content":{"rendered":"

<\/p>\n

\ubaa9\ucc28<\/strong><\/p>\n

1. Abstract<\/p>\n

2. Introduction
\n 1) Chromatography
\n 2) HPLC (High Performance Liquid Chromatography, \uace0\uc131\ub2a5 \uc561\uccb4 \ud06c\ub85c\ub9c8\ud1a0\uadf8\ub798\ud53c)
\n 3) HPLC\uc758 \uc791\ub3d9 \ubc29\uc2dd
\n 4) HPLC detector
\n 5) \uc561\uccb4 \ud06c\ub85c\ub9c8\ud1a0\uadf8\ub798\ud53c-\uc9c8\ub7c9\ubd84\uc11d (LC\/MC)
\n 6) ESI (Electrospray Ionization)
\n 7) SQ (Sequential Quadrupole)
\n3. Materials & Methods<\/p>\n

4. Results
\n 1) LC-MS\ub97c \ud1b5\ud574 \uce21\uc815\ud55c \ubd84\uc790\ub7c9\uacfc \uc774\ub860\uc801 \ubd84\uc790\ub7c9\uc744 \ube44\uad50\ud558\ub77c.
\n 2) LC-MS\ub97c \ud1b5\ud574 \uac80\ub7c9\ud55c \ucee4\ud53c\uc640 \ub179\ucc28(\uc774\ubc88 \uc2e4\ud5d8\uc5d0\uc11c\ub294 \ucee4\ud53c\uc640 \ud56b\uc2dd\uc2a4)\uc758 caffein \ud568\ub7c9\uacfc \uc2e4\uc81c \ud45c\uc2dc\ub418\uc5b4\uc788\ub294 caffein \ud568\ub7c9\uc744 \ube44\uad50\ud558\ub77c.
\n 3) \ubbf8\uc9c0\uc758 \uc2dc\ub8cc(\ubbf8\uc720 \ucee4\ud53c) \ud568\uc720\ub41c caffeine\uc758 \ub18d\ub3c4\ub97c \uacc4\uc0b0\ud558\ub77c.<\/p>\n

5. Discussions
\n 1) \uac80\ub7c9\ud55c \ucee4\ud53c\uc640 \ub179\ucc28(\uc774\ubc88 \uc2e4\ud5d8\uc5d0\uc11c\ub294 \ucee4\ud53c\uc640 \ud56b\uc2dd\uc2a4)\uc758 caffeine \ud568\ub7c9\uc774 \ub2e4\ub978 \uc774\uc720\ub97c \uc0dd\uac01\ud574\ubcf4\uc2dc\uc624.<\/p>\n

6. References<\/p>\n

\ubcf8\ubb38\ub0b4\uc6a9<\/strong><\/p>\n

\u2160. Abstract
\n\uc774\ubc88 \uc2e4\ud5d8\uc740 LC\/MS\ub97c \uc774\uc6a9\ud558\uc5ec \ucee4\ud53c\uc5d0 \uc788\ub294 caffeine\uc744 \uc815\ub7c9 \ubd84\uc11d\ud558\uc600\ub2e4. \uc774\uc678\uc5d0\ub3c4 \uc2dc\uc911\uc5d0 \ud310\ub9e4\ud558\ub294 \ucee4\ud53c\uc640 \ud56b\uc2dd\uc2a4, \ubbf8\uc9c0 \uc2dc\ub8cc\uc5d0 \uc788\ub294 caffeine\ub3c4 \uac80\ub7c9\ud574 \ubcf4\uc558\ub2e4. \uc2e4\ud5d8 \uacb0\uacfc, LC-MS\ub97c \ud1b5\ud574 \uce21\uc815\ud55c \uc774\uc628\ud654\ub41c \uc0c1\ud0dc\uc758 caffeine\uc758 \ubd84\uc790\ub7c9\uc740 195.1 g\/mol\uc774\uc5c8\ub2e4. \uc5ec\uae30\uc11c \uc218\uc18c \uc774\uc628\uc758 \ubd84\uc790\ub7c9\uc778 1 g\/mol\uc744 \uc81c\uc678\ud558\uba74 194.1 g\/mol\uc774\uba70, \uc774\ub860\uc801\uc778 \ubd84\uc790\ub7c9\uc778 194.194 g\/mol\uacfc \ube44\uad50\ud558\uc5ec \uac70\uc758 \uc77c\uce58\ud558\ub294 \uacb0\uacfc\ub97c \ubcf4\uc600\ub2e4. (\uc624\ucc28\uc728 0.048 %) \ub2e4\uc74c\uc73c\ub85c \ucee4\ud53c\uc758 caffeine\uc740 \uc2e4\uc81c \ud45c\uc2dc\ub41c \ud568\ub7c9 400 ppm\ubcf4\ub2e4 \ud06c\uac8c \ub0ae\uc740 281.4 ppm\uc744 \uc5bb\uc5c8\uace0, \uc624\ucc28\uc728\uc740 29.65%\ub85c \ub192\uc740 \ud3b8\uc774\uc5c8\ub2e4. \ubc18\uba74 \ud56b\uc2dd\uc2a4\uc758 caffeine\uc740 \uc2e4\uc81c \ud45c\uc2dc\ub41c \ud568\ub7c9\uc778 240 ppm\uacfc \uac70\uc758 \ube44\uc2b7\ud55c 249.9 ppm\uc744 \uc5bb\uc5c8\uace0, \uc624\ucc28\uc728\uc740 4.125%\ub85c \ube44\uad50\uc801 \ub0ae\uc558\ub2e4. \ub9c8\uc9c0\ub9c9\uc73c\ub85c \ubbf8\uc9c0\uc758 \uc2dc\ub8cc\ub97c LC-MS\ub97c \ud1b5\ud558\uc5ec \uac80\ub7c9\ud55c caffeine\uc758 \ub18d\ub3c4\ub294 2.453 ppm\uc774\uc5c8\ub2e4. \uc5ec\uae30\uc5d0 \ud76c\uc11d\ubc30\uc218 100\uc744 \uacf1\ud558\uba74 245.3 ppm\uc774 \ub41c\ub2e4. \ub530\ub77c\uc11c \ubbf8\uc9c0\uc758 \uc2dc\ub8cc\uc5d0 \ud568\uc720\ub41c caffeine\uc758 \ub18d\ub3c4\ub294 245.3 ppm\uc774\ub2e4. \ub354 \ub098\uc544\uac00 \uc77c\ubc18 \ucee4\ud53c\uc640 \ube44\uad50\ud558\uc600\uc744 \ub54c, \ubbf8\uc9c0\uc758 \uc2dc\ub8cc\ub85c \uc0ac\uc6a9\ud55c \ucee4\ud53c\uc5d0\uc11c\uc758 caffeine \ud568\ub7c9\uc774 \ub354 \ub0ae\uc558\ub2e4. \uc77c\ubc18 \ucee4\ud53c\ubcf4\ub2e4 \ubbf8\uc9c0\uc758 \uc2dc\ub8cc(\ubbf8\uc720 \ucee4\ud53c)\uac00 \ub354 \uc5f0\ud55c \ucee4\ud53c\ub77c\uace0 \ud560 \uc218 \uc788\ub2e4.<\/p>\n

\u2161. Introduction
\n– \uc2e4\ud5d8 \ubaa9\ud45c : LC\/MS\ub97c \uc774\uc6a9\ud558\uc5ec \ucee4\ud53c\uc5d0 \uc788\ub294 \uce74\ud398\uc778\uc744 \uc815\ub7c9 \ubd84\uc11d\ud55c\ub2e4.
\n1. Chromatography
\nChromatography\ub294 \uace0\uc815\uc0c1\uacfc \uc774\ub3d9\uc0c1\uc744 \uc774\uc6a9\ud558\uc5ec \uc5ec\ub7ec \uac00\uc9c0 \ubb3c\uc9c8\ub4e4\uc774 \uc11e\uc5ec \uc788\ub294 \ud63c\ud569\ubb3c\uc744 \uc774\ub3d9\uc18d\ub3c4 \ucc28\uc774\uc5d0 \ub530\ub77c \ubd84\ub9ac\ud558\ub294 \ubc29\ubc95\uc774\ub2e4.<\/p>\n

\ucd9c\ucc98 : \ud574\ud53c\ucea0\ud37c\uc2a4<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\ubaa9\ucc28 1. Abstract 2. Introduction 1) Chromatography 2) HPLC (High Performance Liquid Chromatography, \uace0\uc131\ub2a5 \uc561\uccb4 \ud06c\ub85c\ub9c8\ud1a0\uadf8\ub798\ud53c) 3) HPLC\uc758 \uc791\ub3d9 \ubc29\uc2dd 4) HPLC detector 5) \uc561\uccb4 \ud06c\ub85c\ub9c8\ud1a0\uadf8\ub798\ud53c-\uc9c8\ub7c9\ubd84\uc11d (LC\/MC) 6) ESI (Electrospray Ionization) 7) SQ (Sequential Quadrupole) 3. Materials & Methods 4. Results 1) LC-MS\ub97c \ud1b5\ud574 \uce21\uc815\ud55c \ubd84\uc790\ub7c9\uacfc \uc774\ub860\uc801 \ubd84\uc790\ub7c9\uc744 \ube44\uad50\ud558\ub77c. 2) LC-MS\ub97c \ud1b5\ud574 \uac80\ub7c9\ud55c \ucee4\ud53c\uc640 \ub179\ucc28(\uc774\ubc88 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[9038,4587,23383,19487,23385,20020,20021,23384,8319,23382],"class_list":["post-18357","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-formaldehyde-resin","tag-hplc","tag-lc-mc","tag-sql","tag-23385","tag-20020","tag-20021","tag-23384","tag-8319","tag-23382"],"_links":{"self":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/posts\/18357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/comments?post=18357"}],"version-history":[{"count":0,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/posts\/18357\/revisions"}],"wp:attachment":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=18357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/categories?post=18357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/tags?post=18357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}