{"id":38689,"date":"2026-04-27T09:02:02","date_gmt":"2026-04-27T00:02:02","guid":{"rendered":"https:\/\/blog.agentsoft.co.kr\/index.php\/2026\/04\/27\/38689\/"},"modified":"2026-04-27T09:02:02","modified_gmt":"2026-04-27T00:02:02","slug":"%ec%8b%9d%ed%92%88%eb%8f%85%ec%84%b1%ed%95%99-in-silico-toxicology-%eb%98%90%eb%8a%94-in-silico-adme-study%ec%97%90-%eb%8c%80%ed%95%9c-%eb%8f%99%ed%96%a5-%ec%a1%b0%ec%82%ac","status":"publish","type":"post","link":"https:\/\/blog.agentsoft.co.kr\/index.php\/2026\/04\/27\/38689\/","title":{"rendered":"\uc2dd\ud488\ub3c5\uc131\ud559 ) in silico toxicology \ub610\ub294 In silico ADME study\uc5d0 \ub300\ud55c \ub3d9\ud5a5 \uc870\uc0ac"},"content":{"rendered":"

<\/p>\n

\ubaa9\ucc28<\/strong><\/p>\n

1. \uc5f0\uad6c\ub3d9\ud5a5
\n2. \ucd9c\ucc98 \ubc0f \ucc38\uace0\ubb38\ud5cc<\/p>\n

\ubcf8\ubb38\ub0b4\uc6a9<\/strong><\/p>\n

1. \uc5f0\uad6c\ub3d9\ud5a5
\n 1) In silicotoxicology models and databases as FDA Critical Path Initiative toolkits. (2011)
\n \uc774 \uc5f0\uad6c\ub294 \uc778\uc2e4\ub9ac\ucf54 \ub3c5\uc131\ud559 \ubaa8\ub378\uacfc \ub370\uc774\ud130\ubca0\uc774\uc2a4\uac00 FDA\uc758 \uc911\uc694 \uacbd\ub85c \uc774\ub2c8\uc154\ud2f0\ube0c \ub3c4\uad6c\ub85c\uc368 \uc5b4\ub5a0\ud55c \ubaa9\uc801\uc744 \uac00\uc9c0\uba70 \uc5b4\ub5a4 \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud558\ub294\uc9c0\uc5d0 \ub300\ud574 \uc124\uba85\ud55c\ub2e4. \uc774 \ub3c4\uad6c\ub4e4\uc740 \uc57d\ubb3c \uac1c\ubc1c\uacfc \uaddc\uc81c\uc801 \ud3c9\uac00 \uacfc\uc815\uc5d0\uc11c QT \uac04\uaca9\uc758 \uc5f0\uc7a5\uc774\ub098 \uc57d\ubb3c\uc5d0 \uc758\ud55c \uc778\uc9c0\uc9c8\uc99d \uac19\uc740 \uac00\ub2a5\ud55c \ubd80\uc791\uc6a9\ub4e4\uc744 \uc608\uce21\ud558\uae30 \uc704\ud574 \uc0ac\uc6a9\ub41c\ub2e4. \ub354 \ub098\uc544\uac00, \uc774\ub294 \uc57d\ubb3c \ub300\uc0ac \ubc0f P450 \ud6a8\uc18c \uc5b5\uc81c\uc5d0 \ub300\ud55c \uc778\uc2e4\ub9ac\ucf54 \ubaa8\ub378\ub9c1\uc758 \uc911\uc694\uc131\uc744 \uac15\uc870\ud558\uba70, \uc2dd\ubb3c \uc131\ubd84\uc758 \uac04 \ub3c5\uc131 \ud3c9\uac00\uc5d0 \ub300\ud55c \uc778\uc2e4\ub9ac\ucf54 \uc2a4\ud06c\ub9ac\ub2dd \ubc29\ubc95\uc744 \ud3ec\ud568\ud55c\ub2e4.<\/p>\n

2) The Pros and Cons of the In-silico Pharmaco-toxicology in Drug Discovery and Development. (2013)
\n \uc774 \ub17c\ubb38\uc740 \uc57d\ubb3c \ubc1c\uacac \ubc0f \uac1c\ubc1c \uacfc\uc815\uc5d0\uc11c \ud654\ud559 \uad6c\uc870\ub97c \uae30\ubc18\uc73c\ub85c \ud55c \ub3c5\uc131 \uc608\uce21\uc5d0 \uae30\uc5ec\ud558\ub294 \ub2e4\uc591\ud55c \uc778\uc2e4\ub9ac\ucf54 \ubaa8\ub378\uc5d0 \ub300\ud574 \ub2e4\ub8ec\ub2e4. \ud2b9\ud788, \uad6c\uc870-\ud65c\uc131 \uad00\uacc4(SAR)\uc640 \uc591\uc801 \uad6c\uc870-\ud65c\uc131 \uad00\uacc4(QSAR) \ubaa8\ub378\uc744 \uc911\uc2ec\uc73c\ub85c \uc124\uba85\ud55c\ub2e4. \uc774 \ubaa8\ub378\ub4e4\uc740 \ud56d\uc0b0\ud654\uc81c\uac00 \uc554 \uc608\ubc29 \ubc0f \uce58\ub8cc\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uacfc \uac19\uc774 \ub17c\ub780\uc774 \ub9ce\uc740 \uc8fc\uc81c\ub97c \ud0d0\uc0c9\ud558\ub294 \ub370 \uc788\uc5b4 \uc720\uc6a9\ud558\uac8c \uc0ac\uc6a9\ub420 \uc218 \uc788\ub2e4. \ub610\ud55c, \uc774 \ub17c\ubb38\uc740 \ub3c5\uc131 \ud3c9\uac00\uc5d0\uc11c \uc778\uac04 \ub370\uc774\ud130\uc5d0 \ub300\ud55c \ubbfc\uac10\ub3c4\ub97c \uace0\ub824\ud558\ub294 \uc0c8\ub85c\uc6b4 \uc811\uadfc \ubc29\ubc95\uc744 \uc81c\uc2dc\ud55c\ub2e4.<\/p>\n

\ucd9c\ucc98 : \ud574\ud53c\ucea0\ud37c\uc2a4<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\ubaa9\ucc28 1. \uc5f0\uad6c\ub3d9\ud5a5 2. \ucd9c\ucc98 \ubc0f \ucc38\uace0\ubb38\ud5cc \ubcf8\ubb38\ub0b4\uc6a9 1. \uc5f0\uad6c\ub3d9\ud5a5 1) In silicotoxicology models and databases as FDA Critical Path Initiative toolkits. (2011) \uc774 \uc5f0\uad6c\ub294 \uc778\uc2e4\ub9ac\ucf54 \ub3c5\uc131\ud559 \ubaa8\ub378\uacfc \ub370\uc774\ud130\ubca0\uc774\uc2a4\uac00 FDA\uc758 \uc911\uc694 \uacbd\ub85c \uc774\ub2c8\uc154\ud2f0\ube0c \ub3c4\uad6c\ub85c\uc368 \uc5b4\ub5a0\ud55c \ubaa9\uc801\uc744 \uac00\uc9c0\uba70 \uc5b4\ub5a4 \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud558\ub294\uc9c0\uc5d0 \ub300\ud574 \uc124\uba85\ud55c\ub2e4. \uc774 \ub3c4\uad6c\ub4e4\uc740 \uc57d\ubb3c \uac1c\ubc1c\uacfc \uaddc\uc81c\uc801 \ud3c9\uac00 \uacfc\uc815\uc5d0\uc11c QT \uac04\uaca9\uc758 \uc5f0\uc7a5\uc774\ub098 \uc57d\ubb3c\uc5d0 \uc758\ud55c \uc778\uc9c0\uc9c8\uc99d […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[48499,48498,48500,48497],"class_list":["post-38689","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-in-silico-adme-study","tag-in-silico-toxicology","tag-48500","tag-48497"],"_links":{"self":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/posts\/38689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/comments?post=38689"}],"version-history":[{"count":0,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/posts\/38689\/revisions"}],"wp:attachment":[{"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/media?parent=38689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/categories?post=38689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.agentsoft.co.kr\/index.php\/wp-json\/wp\/v2\/tags?post=38689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}